Effect of hypertension on retinopathy and nephropathy in diabetic patients

ABSTRACT

This study investigated the impact of hypertension on the prevalence of diabetic nephropathy and retinopathy. Two hundred hypertensive diabetic patients and two hundred non hypertensive diabetic patients were investigated for fundus changes and renal changes. The mean values and standard deviation for diabetic hypertension groups were-urea [27.8+/-11 mg/dl], creatinine [0.9+/-0.27 mg/dl], Microalbuminuria <30mg [16 +/-6.9 mg/l] Microalbumiuria >30mg [100+/-79], creatinineclearance [81.5+/-28.6 ml/min], Glycated HB [9.82+/-3.01%], FBS[190+88.3 mg/dl], cholesterol [214+/-78 mg/dl] triglyceride [167+/-99.2 mg/dl]. color blindness 15 cases out of 110 cases and retinopathy 23 cases out of 123 cases. For the non hypertension group the values and standard deviation were Urea [25.5 +/-11.3 mg/dl], Creatinine [0.82+/-0.22 mg/dl], Microalbuminu <30mg [16.7 +/-6.1 mg/l/day], microalbuminuria >30mg [104 +/-82 mg/l], Creatinineclearance [91.9 +/-27.8 mum], Glycated HB [9.42 +/-2.69%], FBS [192+/-83.9mg/dl]. cholesterol [218+/-68.3 mg/dl], Triglyceride [186+/-139 mg/dl] Color blindness l5cases out of 137cases.and retinopathy 13 case out of 127 case . There was a statistical significant difference for urea [p<0.05], creatinine [p<0.002], Creatinine clearance [p<0.001] and retinopathy [p<0.04] for the hypertensive group in comparison to non hypertensive group. There was also non significant decrease in renal function as micro albuminuria increase above 30 mg in both groups