Goblet cell sialomucin, sulphomucin and O-acylated sialomucin content in ulcerative colitis

ABSTRACT

This study was carried out to investigate the pattern of goblet cell sialomucin, sulphomucin and O-acylated sialomucin in ulcerative colitis. Endoscopic biopsy material was obtained from 15 cases of ulcerative colitis, and stained with High iron diamine / alcian blue and periodic acid borohydrate saponification PAS technique. The mucin profile was correlated with degree of dysplasia. Three [27.27 %] out of 11 cases without dysplasia and one [25 %] out of 3 cases with dysplasia showed increased sialomucin content. The content, of O-acylated sialomucin was normal in 66.66%and reduced in 33.33% of the cases. The reduction in the O-acylated sialomucin was seen in 75% of the dysplastic lesions and in 18.18% of the cases with no evidence of dysplasia. It can be concluded that composition of mucin is changed in ulcerative colitis. An increase in sialomucin and reduction in O-acylated sialomucin content was seen in some of the cases, the later change was associated more frequently with dysplasia