Nucleolar organizer regions in schistosomal cystitis with or without associated carcinoma

ABSTRACT

Silver colloid stain was used to count the number of A[g]NOR[s]- associated proteins in paraffin section of chronic cystitis, schistosomal cystitis and neoplastic lesions of urinary bladder. The mean number of AgNORs per nucleus is 1.7 in schistosmal cystitis, 2.9 in dysplasia, 3.0 in dysplasia wth schistosomal cystitis, 3.7 in squamous cell carcinoma, 4.9 in squamous cell carcinoma associated with schistosomal cystitis, 4.4 in transitional cell carcinoma and 6.0 in transitional cell carcinoma associated with schistosomal cystitis. It appears that there is a statistically significant different in the numbers of V [1] Between chronic cystitis with or without schistomoisis and dysplastic lesions; [2] Between dysplastic lesions with or without schistosomiasis and malignant lesions; [3] Between cystitis with or without schistosomiasis and malignant lesions; [4] Between neoplasia associated with schistosomiasis and neoplasia in the absence of schistosomiasis. The results indicate that this histochemical technique can be of value in diagnostic problems of border line cases and may have a role in the differentiation between chronic cysttis, dysplasia and carcinoma of the bladdere