role of orcien alcian blue in the discrimination between dysplasia and reactive hyperplasia in ulcerative colitis

ABSTRACT

30 cases of different stages of ulcerative colitis were stained by Hx and E and orcien alcian blue to study the mucin changes in cases of dysplasia and reactive hyperplasia. 6 out of the 8 villous patterns encountered, although no morphologic evidence of dysplasia is encountered, yet the histochemical results were markedly deviated from normal. All 8 cases with adenomatous patterns proved to reveal mucin changes in the form of sialomucins predominance. The lining mucosa away in cases of ulcerative colitis revealed a predominance of sialomucins and it is called transitional mucosa which must be regarded with great caution