Systolic time intervals in uncomplicated non insulin dependent diabetics in the absence of clinical data of ischaemic heart disease, relation between blood glucose level and PEP/LVET

ABSTRACT

Systolic time intervals were measured in 55 non insulin dependent diabetic patients having no clinical and electrocardiographic evidence of ischaemic heart disease [29 male and 26 female with mean age 50.3 +/- 11.5]. Results were compared to 19 normal subjects [12 male and 7 female with age 44.6 +/- 15.6]. PEPI was found prolonged among diabetics [133.7 +/- 8.2] compared to normals [129.9 +/- 5.7], P<0.05. LVETI was found shortened in diabetics [408.02 +/- 12.5] compared to the control group [416.4 + 9.01] P <0.02. QS2 changes were insignificant. The ratio PEP/LVET was significantly increased in diabetics 360.6 +/- 33.02, compared to control group, 339.4 +/- 19.5 P<0.02. Echocardiographic EF and FS showed no significant difference in diabetics compared to the control group. The ratio PEP/LVET showed positive linear relationship with the blood glucose levels in diabetics [r = +0.77]. Thus, it was apparent that systolic time intervals as sensitive parameter of left ventricular function showed variations in non insulin diabetics compared to normal subjects as LV function was affected in diabetics while echocardiographic EF and FS showed no significant difference. So, these parameters could by applied serially for early detection of development of diabetic cardiomyopathy