Haemolytic-uraemic syndrome: therapy and prognostic features

ABSTRACT

Thirty five children with Haemolytic-Uraemic Syndrome [HUS] were seen between July 1989 to December, 1990 at the Department of Paediatrics, King Edward Medical College and Mayo Hospital, Lahore. All developed HUS following an episode of diarrhoea or respiratory infection. Mean age at presentation was 19 months and peak incidence of disease was in summer months. Twenty four of the thirty five children [69%] had a favourable outcome with complete recovery. Eight children [23%] died in the acute phase of the illness and three children developed chronic renal failure [8%]. This study indicates that younger age, shorter period of anuria, absent CNS manifestations and institution of early peritoneal dialysis are associated with a good outcome: