Coagulation status and fibrinolytic activity in normal and abnormal pregnancy: case control study

ABSTRACT

Haemostatic and fibrinolytic activity changes during normal pregnancy particularly at the time of the placental separation. This study was designed to detect the changes in fibrinogen, plasminogen and factor XIII; and fibrin degradation products [FOPs], antiplasminogen and for the first time the "D-dimer" in different types of pregnancy associated complications. Twenty seven patients with aberrations of the pregnancy during first and second trimester and 26 patients with hypertensive disorders of pregnancy were compared to the 36 normal pregnancies. Plasminogen, fibrinogen and factor XIII showed a significant reduction in both abnormal groups compared to the normal pregnancy. The FOPs, antiplasminogen and the D-dimer, on the other hand showed a significant increase. These findings suggest using some of these parameters in early diagnosis of placental-associated abnormalities of the pregnancy