Spectrophotometric determination of amoxicillin and cefadroxil using 3-methyl-2bencothiazolone hydrazone hydrochloride
Alexandria Journal of Pharmaceutical Sciences. 1993; 7 (3): 211-213
Dans Anglais
| IMEMR
| ID: emr-26936
ABSTRACT
A spectrophotometric method was described for the determination of amoxycillin and cefadroxil. The method was based on the reaction of these drugs with 3-methyl-2-benzothiazolone hydrazone hydrochloride [MBTH] in the presence of cerric ammonium sulfate. The colored products were estimated spectrophotometrically at 530 nm and 511 nm for amoxycillin and cefadroxil, respectively. Beer's Law was valid over the concentration range 10-50 mug ml -1. The method was applied successfully to the analysis of dosage forms. Relative st and ard deviations for the assay of both drugs in commercial preparations were less than 1%
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Indice:
Méditerranée orientale
Sujet Principal:
Spectrophotométrie
/
Céfadroxil
/
Hydrazones
langue:
Anglais
Texte intégral:
Alex. J. Pharm. Sci.
Année:
1993
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