effect of praziquantel treatment on the liver functions, worm burden, and granuloma size using two drug regimen in murine schistosoma mansoni infection

ABSTRACT

The effect of single dose of praziquantel [400 mg/kg] or two doses on two consecutive days was studied in mice infected with S. mansoni. With the single dose there was improvement in the serum protein pattern, towards pre-infection values and a transient rise in serum transminases which soon declined to normal Improvement was more evident after using two doses of praziquantel [P < 0.001]. Worms were eradicated by 70%, 77% and 80% after the single dose and by 88%, 92% and 95% after two doses. Granuloma size was reduced by 50%, 54% and 60% after single dose and by 58% and 73% respectively after 10, 20, and 30 days from treatment