How aluminum is taken up by red blood cells: a study in relation to hypochromic microcytic anemia in hemodialyzed patients
Medical Journal of the Islamic Republic of Iran. 1993; 7 (2): 87-93
Dans Anglais
| IMEMR
| ID: emr-29323
ABSTRACT
Investigation of aluminium uptake by human erythrocytes was the major aim of this study. Packed red blood cells were incubated in Earle's medium [pH 7.4] containing varying concentrations of aluminium [0-160 micro g/l] as A1K[SO[4]][2] and aluminium content of the cells were determined using flameless atomic absorption. There was significant increase in aluminium content of the cells. Addition of 5 mM glucose caused an elevation of red cell aluminium, whereas depletion of red cells from ATP caused a marked reduction in aluminium uptake. Both ouabain and vanadate, when added to the medium, caused a significant reduction in aluminium uptake in line with a decrease in ATP ase activity
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Indice:
Méditerranée orientale
Sujet Principal:
Aluminium
/
Anémie hypochrome
/
Défaillance rénale chronique
langue:
Anglais
Texte intégral:
Med. J. Islamic Rep. Iran
Année:
1993
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