Effect of repeated exposure to isoflurane on the liver of stressed rats Histopathological and histochemical study

ABSTRACT

Twenty four male white rats divided into 4 equal groups were used in this study. Group I was kept as a control. Group II was exposed to 1% isoflurane in oxygen 30 minutes every other day for 12 exposures. The rats of groups III and IV were subjected for 20 minutes of stress by hitting on their cages in non rhythmic way. Group III was exposed to 1% isoflurane in O2 for 12 exposures like group II. Liver sections stained with Hx and E and PAS showed no histopathological changes in groups I and III, focal fatty change in group II and vacular degeneration with ballooning of the hepatocytes in group IV. Mild depression of acid phosphatase, lactic and succinic dehydrogenase enzyme activity in stressed rats in groups III and V. These changes were mild and signify no pathological importance