Respiratory function profile in response to some narcotic analgesics

ABSTRACT

Thirty ASAI adult volunteers classified into 3 equal groups were chosen. Their mean age and body weight were 27 years and 65.4 kg, respectively. Pentazocine [0.3 mg/kg], butorphanol [0.03 mg/kg] and morphine [0.16 mg/kg] were injected i.m. to the members of groups 1, 2 and 3, respectively. In all members of the three groups recording of respiratory rate and d battery of respiratory function tests were done before, half an hour and one hour after the injection of the drugs. These tests include VC, FVC, FEVI, FEER [0.2-1.2] and FMEFR [25-75%]. No significant changes in the studied parameters were observed with pentazocine, while significant decrease in respiratory rate was recorded half an hour after morphine and one hour after both butorphanol and morphine administration. The two drugs had no significant effect on other respiratory function tests. There was significant reduction in respiratory rate in both butorphanol and morphine groups half an hour and one hour after the injection on comparison with pentazocine group