Some new-xanthotoxin derivatives with expected biological activity

ABSTRACT

Xanthotoxin-4-Sulphonyl chloride [I] was reacted with some -sulpha derivatives to give II and with p-aminobenzoic acid to give IIIc which converted to the corresponding esters [IV], primary and secondary amides [V and VI]. p-Aminodiphenyl-amine was reacted with I to give Xa which converted to acridine and to phenothiazene derivatives [XI and XII]. The sulphonic acid ester [XIIIc] was prepared from I and p-hydroxybenzaldehyde which then reacted with hippuric acid to give the oxazolin-5-one derivative [XIV]. Another type of Xanthotoxin sulphonamides [XXI] were prepared from 4-aminoxanthotoxin and the corresponding sulphonyl chloride