Does adenosine functions as a retaliatory metabolite in the heart?

ABSTRACT

Adenosine formation is augmented when the O2 supply is inadequate. Cardiac actions of adenosine can increase O2 supply [vasodilation] and decrease O2 consumption. We suggest that adenosine serves as a negative-feedback signal to correct an imbalance betweenO2 supply and consumption, thus acting as a cardioprotective metabolite