advantage of using measles vaccines cultured on human diploid cells in children allergic to egg

ABSTRACT

Forty-one children with history of egg-allergy were classified according to the history of clinical reaction to egg into three grades to study the association between clinical signs and symptoms of egg allergy and measles vaccine skin tests. A skin prick test with whole egg with a positive and negative control was first done, followed by an intradermal test of 110 dilution of measles vaccine. A significant association was found between the clinical grading and the strength of reaction to egg skin prick test [p = 0.008]; also a significant relation was found between the intradermal measles skin test and the egg skin prick test [p = 0.03]. Eight children with a positive measles intradermal test were given measles vaccine cultured on human diploid cells [Moraten Berna]. Children with negative measles intradermal test were vaccinated with the usual vaccine. No reactions were reported