study of glycosaminoglycans and some lysosomal enzymes in the serum and synovial fluid in osteoarthritis

ABSTRACT

The study was done on 25 patients with osteoarthritis as well as 25 healthy persons as a control group. Determination of serum beta-glucuronidase, beta-galactosidase and aryl sulfatase activities as well as serum concentration of glycosaminogylcans and glucuronic acid were done in both groups. The same parameters were determined in the synovial fluid of the patients only. There were significant increase of serum beta-glucuronidase activities, aryl sulfatase activities and glucuronic acid concentration in osteoarthritic patients as compared to control group. There was a significant decrease of serum glycosaminoglycan in osteoarthritic patients as compared to control group. But there was no significant change of beta-glactosidase activities