Myocardial protection: an approach with alterations in cations and trace elements in rats

ABSTRACT

This study was undertaken to investigate the cation and trace element changes in experimentally induced myocardial isehaemia like lesion evoked by isoprenaline. Rats were treated with 30 mg/kg S.C isoprenaline alone or in combination with the calcium entry blocker felodipine 1 mg/kg i.p or the free radical scavenger superoxide 15000 U/kg i.p. Our results showed that the isoprenaline-produced hypocupraernia and hypozincaemia, and the cardiac damage is accompanied by calcium overload, magnesium and zinc depletion, Felodipine and superoxide disinutase altered these changes in different manners. We conclude that manipulations of cardiac cations and trace elements can provide myocardial protections in experimental model of cardiac ischaemia induced by isoprenaline