Serum lipid alterations in retinopathy of type II [non-insulin dependent] diabetes mellitus

ABSTRACT

Fasting serum glucose, fructosamine, lipids, and lipoproteins were measured in 49 non-insulin dependent diabetics. Of these, 15 were without retinopathy, 12 with exudative type, and 22 with proliferative retinopathy. The groups were closely matched for age, sex, and duration of diabetes. The increased serum fructosamin values were significant correlated with high serum glucose in diabetic retinopathy [P< 0.001] and non-retinopaths [P< 0.01]. Nevertheless, all diabetic groups had exhibited no s relationship of serum fructosamine and main lipids or lipoprotien fractions. The means of serum triglyceride [TG], total cholesterol [TCH], very low density lipoprotein cholesterol [VLDL-CH], and low density lipoprotein cholesterol [LDL-CH] were significantly increased with the severity of retinopathy. High density lipoprotein cholesterol [HDL-CH] concentrations in all diabetic groups were comparable to their corresponders of 22 healthy controls. A high ratio of LDL-CH/HDL-CH was observed only in proliferative type [P< 0.05]. Adjustment for different treatment modalities had revealed alteration in serum lipid fractions among other groups