double blind placebo controlled study comparing the CNS and antimuscarinic side effect of amitriptyline and maprotiline

ABSTRACT

A double blind placebo controlled cross over study randomized in a latin square design was conducted at Pharmacology Department of Rawalpindi Medical College on twelve healthy human volunteers of either sex, with ages between 20-25 years and a body weight between 50-60 kg to compare the C.N.S. and antimuscarinic side effects of tricyclic [Amitryptyline] and tetracyclic [Maprotiline] antidepressants Results revealed that amitriptyline causes more sedation than maprotiline. The antimuscarinic effects like dryness of mouth, decrease in salivary volume and impairment of visual accommodation are also more prominent with amitriptyline compared with maprotiline