Effect of some commercial antacids and tea drink on the in-vitro availability of frusemide

ABSTRACT

In this study, the dissolution rate of frusemide as a sparingly soluble diuretic, was determined in the presence of some commercial antacids. The effect of tea, as a conventional drink, on the in vitro availability of the drug in the presence of the selected antacids was also investigated. The obtained results revealed that, availability of frusemide was markedly affected in the presence of the selected antacids. The powdered antacids showed the most prominent effect, while antacid tablets produced the lowest in this respect. Also, a marked reduction in the dissolution rate of frusemide was observed in the presence of both tea and antacids. The observed reduction in the dissolution rate of frusemide with these antacids may be attributed to the chemical interaction, which was proved by IR, UV and TLC studies