Plasminogen, fibrinogen and bradykinins in alveolar osteitis in patients receiving oral contraceptives

ABSTRACT

Two hundred females were examined for the incidence of alveolar osteitis [dry socket], after simple extraction of a mandibular molar. The control group [100 Patients] included 12% positive cases at the middle of their menstrual cycle. In the contraceptive pill users group, the incidence of alveolar osteitis was 36% at the middle of the tablet cycle No cases were reported during menstruation in both groups. The highest levels of plasma plasminogen and bradykjnin were found at the middle of the tablet cycle. These levels were significantly higher than those found at the middle of the menstrual cycle. Blood level of fibrinogen was significantly reduced in females using pills, compared to the control group at the middle of both cycles. A marked elevation of plasminogen and bradvkinin levels was associated with proportionate decrease in the level of fibrinogen in dry socket eases. The difference between the control and pill users groups was significant