Tumor Markers in malignant liver disease its relation to HBsAg and usefulness of its combined use

Alpha-fetoprotein [AFP], carcinoembryonic antigen [CEA] and serum CA19-9 level were determined in 20 patients with primary hepatocellular carcinoma [HCC] and another 20 patients with metastatic liver disease as well as 20 normal healthy subjects. This was done to determine the usefulness of these markers, its combined use in diagnosis of malignant liver disease and to assess the influence of HBsAg on these markers