Assessment of antibody titre in patients with meningococcal meningitis group A versus post vaccination in high risk groups

ABSTRACT

This study have been carried out from March 1992 to April 1994. During this period 125 cases were admitted with meningococcal meningitis. 111 cases [88.8%] were due to Neisseria Meningitides group [A], 11 cases [8.8%] due to N. Meningitides group [W135] and 3 cases [2.4%] due to N. Meningitides group [C]. 20 cases were studied for the antibody titer to N. Meningitides group A during convalescent and 6 months later. 70 individuals of high risk group were studied for the antibody titer 1 month, 6 months and 1 year post-vaccination. There was significant difference in the antibody titer between the sample of patients 6 months post-infection and vaccines 6 months post- vaccination. So, it was concluded that higher antibody titers are produced with systemic infection than following vaccination