Effect of cortisone administration on the histological structure and lipid content of mouse adrenal cortex

ABSTRACT

After a single IM injection of cortisone, the adrenal glands of 9 male mice were taken at different periods of time [3 hours, 2 days and 3 days, 3 at a time]. The histological structure and lipid content have been studied. The results obtained in the present study showed marked narrowing of the adrenal cortex compared to the medulla. This narrowing involved only zona fasciculata and zona reticularis. Zona glomerulosa, however, showed relative broadening in width. Depletion of sudanophilic materials initially occurred followed by a marked increase 2 days after injection