Cerebral malaria with reversible hemiplegia failed to response to parenteral chloroquine and fansidar in Yemen

ABSTRACT

Severe Cerebral Malaria is a serious, life threatening medical emergency, which necessitates immediate hospital management. Quinine and tetracycline are well recognized for its treatment after the appearance of chloroquine, and pyrimethamine-Sulfadoxine resistance [Fansidar] in Africa [East, West], south east Asia, and south and central America. Focal neurological complications such as hemiplegia, cortical blindness or ataxia.etc. are rare. The high risk people are young children 6 months-3 years old, pregnant ladies [primigravida more], nonimmune person or immunocompromized person. Severe Falciparum malaria can present with few or many manifestations in a predisposed person. This case report of 27 years multiparous lady, two weeks post delivery who had headache, fever sweating and brought into hospital with unarousable coma and right sided hemiplegia, hypotension and anemia. She did not respond to parenteral Chloroquine and Fansidar, but recovered full consciousness and movement of quinine HCL and Teracycline