Evaluation of epicoprostanol: a major sterol of ambergris for anti-inflammatory and antipyretic activities

ABSTRACT

The major sterol of epicoprostanol was isolated from ambergris by flash column chromatography. Its identity as epicoprostanol was confirmed by 1H - NMR and 13C - NMR spectroscopy. Epicoprostanol was studied for its anti - inflammatory and antipyretic activities. Epicoprostanol produced a significant inhibition of carrageenan induced paw oedema. The study on antipyretic activity showed, that epicoprostanol produced a significant reduction of yeast - induced hyperthermia in rat