Inclusion complexion of ketoprofen with B-cyclodextrin and hydroxypropyl B-cyclodextrin in water and in solid state

ABSTRACT

Inclusion complexation of ketoprofen with beta -cyclodextrin[beta -CD] and hydroxypropyl beta cyclodextrin [HP beta -CD] in aqueous solutions and in the solid phase were examined by phase solubility diagrams, infrared spectroscopy, and diffraction patterns. Ketoprofen-cyclodextrin inclusion complexes were obtained applying different techniques including spray drying, freeze drying, evaporation under vacuum and co-grinding in presence and absence of water. The dissolution profile of ketoprofen was highly improved in the complexed from compared to non- treated ketoprofen or its physical mixtures with either- beta CD or HP beta-CD in the same ratio