Detection of campylobacter pylori by the biopsy unease test in 250 patients suffering from non ulcer dyspepsia

ABSTRACT

To detect C pylon by using the biopsy urease test [CLO test] [campylobacter like organism]. we chose 250 patients 146 female and 104 male suffering from non ulcer dyspepsia. For every patient upper GIT endoscopy was done 3 times. first time to choose the patient and two antral biopsy for CLD test, second time after one month from the start for CLO test follow-up. The change of colour from yellow to pink means positive CLO test. We found that 69.6%+ve CLO at 20 min and 91.2% at 4h. Follow-up of patients symptoms and correlation with CLO test result showed that 8.8% of patients were-ve CLO test from the start and continued negative for CLO test up to two months. Their dyspeptic symptoms improved after OTT. 91.2% were+ve at start, 61.6% of them become-ve CLO test after OTT [one month period]. 58.8% improved from dyspeptic symptom while 2.8% did not improve up to 2 months. 29.6% of patients showed persistent positivety of CLO test although they received OTT for one month but 2 7.2% improved from symptoms and 2.4% did not improve. After two months the percentage of+ve CLO test increased to 59.2% but 33.6% improved symptomatically, 25.6% did not improve. the percentage of -ve CLO test decreased from 61.6% to 32% 29.2% improved symptomatically and 2.8% did not improved. In conclusion, CLO test is very useful rapid diagnostic test for C. pylori infection and is very useful in follow-up