Evaluation of cyclic adenosine monophosphate [cAMP] and nuclear estrogen receptor [ERn] in mammary tumors of female rats after irradiation and hormonal therapy

ABSTRACT

This study was designed to investigate the effect of hormonal treatment and irradiation on the level of cAMP and ERn in DMBA induced mammary gland carcinoma tissue of female rats. The results showed that tamoxifen has a better advantage in treatment of DMBA-induced mammary gland tumour of female rats than DES. The anti-regression of ERn level cAMP level in verapamil group explores the role of cAMP and calcium ion on the mechanism of ERn. The results with different single doses of gamma radiation revealed the positive relation between the cAMP values and the amount of single radiation dose but this relation is absent with ERn value