analgesic activity of epicoprostanol, the major sterol of ambergris

ABSTRACT

The analgesic activity of epicoprostanol, the major sterol of ambergris was investigated in male mice, using the hot plate method. Epicoprostanol [1, 10, 100 mg/kg i.p.] significantly increased the hot plate reaction times measured at 60 min post injector. P. chlorophenol alanine which depletes central 5 - HT, only inhibited the antinociceptive activities of 1 and 10 mg epicoprostanol, whereas DSP -4, a neurotoxin of central noradrenergic, the nor adrenergic and serotonergic systems may also be involved in this activity of epicoprostanol