Effect of synanthic and ivomec on trichinella spiralis with reference to their serological evaluation

ABSTRACT

Three groups, each of 10 rats, were experimentally infected with Trichinella spiralis larvae [250/rat]. On the 5th week post-infection animals of two groups were treated with a single dose of synanthic [oxfendazole] and ivomec MK-933 at a dose of 5 mg and 0.2 mg/kg b.w., respectively. Efficacy rate of the former was 84.2% and for the later was 72.5% depending on the number of living larvae in the diaphragm. Anti Trichinella spiralis hemagglutinative antibodies were monitored before and after treatment. They were markedly declined two weeks after treatment. This makes passive hemagglutination test a feasible test to evaluate the drug efficacies either in laboratory or field studies