Trials to prepare potent vaccine against salmonella gallinarum pullorum infection

ABSTRACT

To control Salmonella gallinarum-pullorum [S. g-p] infection in chicken, oil adjuvant vaccine of S. g-p was prepared. The vaccine gave significant protection to vaccinated birds, when vaccinated subcutaneously at 2 weeks of age and challenged on 4 and 8 weeks of age. But, the significance of protection decreased in birds challenged on 8 weeks of age, this is due to developing of age resistance. The vaccine reduced significantly the shedding of S. g-p in vaccinated birds during the observation period compared with non vaccinated control. The bacteriological examination of the sacrificed birds at the end of observation periods indicated that the vaccine reduces the presence of S. g-p organism in vaccinated birds compared with non vaccinated control. It seems from the available literature that the present study is the first record of studying the effect of inactivated S. g-p oil adjuvant vaccine on shedding of S. g-p from infected chickens. The use of S. g-p oil adjuvant vaccine is recommended to protect the exposed chicken and to reduce the possibility of developing carriers