Effect du pentobarbital sur l'adp ribosylation

ABSTRACT

Pentobarbital an inhibitor of respiratory chain at site II stimulates mitochondrial ADP ribosylation of glia cells. Results show an increase of approximaely 30% of the ADP ribosyl transferase activity under pentobarbital treatment. ADP ribosyl transferase modifies two major mitochondrial proteins at molecular weight 50 and 80 KDa. The pentobarbital has been reported to induce neobiogenesis of mitochondria with enhancement of mitochondrial DNA synthesis. The stimulation of ADP ribosyl transferase activity under respiratory chain inhibition suggest the implication of this effect on neobiogenesis of mitochondria