Utilization of N-halouccinimide for semi-microdetermination of azapropazone in bulk powder and pharmaceutical formulations
Egyptian Journal of Pharmaceutical Sciences. 1996; 37 (1-6): 189-198
Dans Anglais
| IMEMR
| ID: emr-40790
ABSTRACT
The utilization of N-bromosuccinimide [NBS] and N-chlorosuccinimide [NCS] for titrimetric determination of anti-inflammatory drug azapropazone was described. The study of stoichiometry of the reactions revealed that 1 mole of azapropazone reacts with 4 moles NBS and 2 moles of NCS. The optimum time for complete the reaction was found to be 10 minutes in cases of NBS and NCS. The method was successfully applied for the determination of azapropazone in bulk powder and prolixan capsules. The reaction product of azapropazone with NBS was isolated and investigated by instrumental analysis and reaction pathway was proposed. Also, suggested reaction pathway for investigated drug with NCS was proposed
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Indice:
Méditerranée orientale
Sujet Principal:
Poudres
/
Succinimides
/
N-Bromo-succinimide
/
Préparations pharmaceutiques
/
Titrimétrie
langue:
Anglais
Texte intégral:
Egypt. J. Pharm. Sci.
Année:
1996
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