Cutaneous meningioma: clinicopathologic and immunohisto-chemical features of two cases with a brief review of the literature

ABSTRACT

Cutaneous meningiomas are rare lesions of the scalp and back which are generally present at birth but may be detected during childhood or early adulthood. Two cases are described in the paravertebral [D4] region of a 24-year old man and in the parietal region of a 2-year-old girl. Diagnostic histological features includes psammoma bodies, small collagenous bodies and varying degrees of meningiothelial proliferation. Cutaneous meningiomas show extensive ultrastructural and immunophynotypic similarities to intracranial meningiomas including widespread expression of vimentin and epithelial membrane antigen. Cutaneous meningiomas probably originate from arachnoid cell nests misplaced into the skin during embryogenesis and occur around sensory organs, cranial and peripheral nerves