effect of alteration in thyroid functions on the oxidant generation

ABSTRACT

This study examined the effect of hyper and hypothyroidism on lipid peroxide, superoxide dismutase and total thiol group. Forty-nine subjects were included and divided into three groups Fourteen patients suffering from hypothyroidism, their mean age +/- SE was 46.07 +/- 1.2 years, sixteen patients suffering from hyperthyroidism, their mean age +/- SE was 34.63 +/- 2.05 years and nineteen normal individuals as a control group, their socioeconomic standard matched the previous two groups. Hypothyroidism tended to diminish lipid peroxidation compared with the control group. On the other hand, hyperthyroidism patients showed significant increase in serum lipid peroxide compared with controls. In addition, superoxide dismutase levels were significantly diminished in two groups. Further investigation after the adjustment of thyroid hormones seems to be essential