Ras oncoprotein level and urinary enzymes activity as sensitive indicators of renal injury in acute and chronic renal failure

ABSTRACT

Sixty-one patients with renal failure and ten healthy controls were included in this study. Patients were subdivided into three groups; group I included 20 patients with acute renal failure [ARF], group II included 20 patients with chronic renal failure [CRF] and group III included 21 patients with renal impairment [RI]. Serum ras oncoprotein was significantly higher in patients with ARF, CRF and RI compared with the controls. Ras oncoprotein level, sialic acid level and urinary excretion of the studied enzymes were not changed significantly with increased degrees of albuminuria or with the presence of casts, RBCs or pus cells in urine. Neither kidney size sonographically nor degree of echogenicity has an effect on the studied bioindices. The study revealed statistically significant correlations between ras oncogene expression and urinary enzymes excreted during renal damage