Comparison between the effects of early schistosoma mansoni infection and the classical inducers phenobarbitone and 3-methylcholanthrene on some hepatic microsomal monooxygenases

ABSTRACT

Hepatic schistosomiasis was induced experimentally in male albino mice using Schistosoma mansoni [S. Mansoni] cercariae for a period of 33-days post infection. Five different levels of infection [60, 120, 180, 300 and 600 cercariae/mouse] were used for the assessment of the comparison of their effects on some hepatic microsomal monooxygenases with those produced by classical enzyme inducers phenobarbitone [PB] and 3-methylcholanthrene [MC]. Similar to the two tested classical inducers, the 33 days post infection of mice with S. mansoni increased the total microsomal protein content [23.6%, 40.5%, 59.9%, 47.2% and 33.7%] and the specific concentration of cytochrome P450 Cyt P450 [26.8%, 35.4%, 71.7%, 56.7% and 48.0%] at all tested infection levels. The maximum increase was recorded at the infection level of 180 cercariae/mouse