Comparison of left ventricular function in insulin and non-insulin dependent diabetes mellitus

ABSTRACT

This study aimed to evaluate the effect of insulin- [IDDM] and non- insulin-dependent [NIDDM] DM on the left ventricular [LV] function. Forty diabetic patients [twenty NIDDM and twenty IDDM] and twenty control cases were included in the study. These patients underwent clinical examination, resting electrocardiogram, treadmill stress test and 2-D and Doppler echocardiography. The patients were divided into two groups [both groups had a negative treadmill exercise test] Group I included ten normal subjects [mean age 31 +/- 7.8 years] compared with IDDM patients [mean age 32.4 +/- 8.1 years] and Group II included ten normal subjects [mean age 44.5 +/- 4.4 years] compared with NIDDM patients [mean age 43 +/- 4.5 years]. It was concluded that diabetic patients without clinical evidence of heart disease had both systolic and diastolic dysfunction. IDDM showed more frequent echocardiographic systolic and diastolic abnormalities than NIDDM independent of coronary artery disease