Role of helicobacter in bile induced injury to gastric endothelium

ABSTRACT

Forty patients were included in this study [22 men and 18 women]. Patients showed variant forms of endoscopic findings ranging from normal finding to severe gastritis or duodenal ulcer. 24 patients [24/40] proved to be Helicobacter pylori [HP] positive by rapid urease test [60%]. Eighteen patients of them [18/24] were gram +ve [75%]. Patients showed bile reflux with bile acid> 1 mmol/I were 24 [24/40] of total [60%], 19 of them were HP positive by rapid urease test [79.1%], 16 of them were also gram +ve for HP, those 16 patients which were DGR +ve, urease +ve and gram +ve were subjected to treatment protocol of triple therapy for 2 weeks. Follow up was done after one month of the end of treatment. 10 patients with DGR showed marked reduction in bile acid concentration [<1 mmol/L], while the rest showed no changes. 13 patients became H. pylori -ve. All DGR -ve patients became H. pylori -ve [P> 0.05]. Histopathological examination of antral biopsy showed no inflammatory responses in 8 patients after eradication of H. pylori [n = 13]