Bone formation and resorption markers in osteoporosis

ABSTRACT

This work was done on 47 primary osteoporotic patients and 28 apparently healthy persons of the same age group. A diagnosis of osteoporosis was performed according to radiological examination of the spine. It was concluded that among bone formation markers studied, both total ALP and bone alkaline phosphatase [B-ALP] and propeptide of type I procollagen [PICP] were significantly higher osteoporotic patients than the controls and higher B-ALP in complicated fractured neck femur than non-complicated patients. Meanwhile, bone resorption markers in the form of urinary calcium, pyridinoline [Pyr] and deoxypyridinoline [D-Pyr] significantly increased in osteoporotic patients of both sexes than the controls. Although complicated patients were higher in females than males, the values showed no significant differences between both sexes. At the same time, both Pyr and D-Pyr correlated significantly with each other. Osteocalcin [OC] correlated with Pyr and PICP correlated significantly with urinary calcium. It was also concluded that biochemical bone markers had the advantage of being non-invasive, accurate and possible to perform repeatedly