Effects of carboplatin on histological, histochemical and cytogenetical changes in albino rat

ABSTRACT

Adult albino rats were treated for one week with carboplatin [40 mg/ kg body weight intraperitoneal daily] and the changes in the tubular apparatus of the kidney were investigated employing histological and enzyme-histochemical The effects were the following The brush borders of the proximal tubules were stuch together and disintegrated; oedema and degeneration of cells were observed and the cytoplasm of cells showed a decrease ofATPase and non-specific esterases. The collagen and reticular fibers were dislocated and disintegrated. Carboplatin caused significant increase in the total number of chromosomal aberrations including structural and numerical anomalies