New furobensopyrones as possible agents for the photochemotherapy of psoriasis with expected monofunctional mode for DNA
Bulletin of Faculty of Pharmacy-Cairo University. 1998; 36 (3): 85-91
Dans Anglais
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ABSTRACT
This work involved the synthesis of linear furobenzopyrone analogs as monofunctional photochemotherapeutic agents, aiming to obtain compounds with increased activity and reduced toxicity. A rough investigation was carried out on the conformation of a new bulky substituent like phenyl group in the furobenzopyrone system to produce compounds that could react with DNA in a monofunctional sense, therefore reducing or eliminating skin phototoxicity or the risk of skin cancer and, at the same time, maintaining the same selectivity of action as psoralen, [linear furobenzopyrone]. So, they have synthesized linear furobenzopyrone derivatives [3a-c and 8a1-6], in which methyl and phenyl groups were systematically varied at the 2, 3, 5, and 9 positions. Preliminary screening for the photosensitizing activity of some of the new analogs have revealed that compound [8a1] is more active as photosensitizer than xanthotoxin [reference], while 3b, c and 8a4-6 are less active. In addition, 3a and 8a2-3 showed no photosensitizing activity
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Indice:
Méditerranée orientale
Sujet Principal:
Photothérapie dynamique
/
Psoriasis
/
Pyrones
/
ADN
langue:
Anglais
Texte intégral:
Bull. Fac. Pharm.-Cairo Univ.
Année:
1998
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