Plasticizers: the insidious blood contaminants. Is it time that the final blood product is more specifically tailored to supply more safe blood?

ABSTRACT

This work determined the presence of DEHP in donated blood before storage inPVC bags as well as the leach of DEHP into the stored blood. Moreover, thedegree and effects of exposure to DEHP in children patients receiving repeatedblood transfusion were evaluated. Four groups of blood samples werecollected. The level of DEHP in all samples were measured using an HPLCsystem. Moreover, groups III and IV were evaluated for liver function[albumin/globulin ratio and serum glutamic pyruvic transaminase] and alpha-2-glycoproteins as indicators for early carcinogenicity. A significant increasein the levels of DEHP was found in the stored blood at different intervalsmatched with the donors blood. Also, children who received bloodtransfusions showed higher levels of DEHP than the controls Moreover, impairedliver functions and higher levels of alpha-2-glycoproteins were determined inthe patient group matched with the control group