Effect of some antioxidant [vitamin A, vitamin E, vitamin C] on plasma and tissues histamine concentrations in diabetic rats

ABSTRACT

The present study was carried out on adult male albino rats, experimentally made diabetics, to clarify whether some of the antioxidants exemplified by vitamin A, vitamin E and vitamin C, had any effect on the elevated plasma and aortic histamine concentrations suggested to be [at least partially] contributing to the early development of atherosclerotic changes in diabetics. In addition, an investigation of their possible effect on the activities of the aortic enzymes, histidine decarboxylase [HDC] and diamine oxidase [DAO] was included as well. Diabetes was induced in rats using alloxan. The animals [confirmed to become diabetics] were treated with the above mentioned drugs for 2 months. Plasma and aortic tissue histamine concentrations, aortic HDC and DAO enzymes activities were determined. Results of the present study had shown a statistically significant alteration in these parameters in the direction of the values recorded in the non-diabetic normal animals groups