Prospective therapeutic effects of fosinopril on some complications of experimentally-induced diabetes in rats

ABSTRACT

This study investigated potential therapeutic beneficial effects of fosinopril on some complications of diabetes in streptozotocin [STZ] diabetic and STZ diabetic hypertensive rats. The experiments were performed on adult female albino rats and diabetes was induced by STZ [45 mg/kg iv]. Fosinopril was administered daily in a dose of 10 mg/kg po for four weeks. The diabetic rats manifested hypertension, bradycardia, loss of body weight and increase in index of heart hypertrophy. A tangible mortality rate was observed. The biochemical profile of both diabetic groups exhibited hyperglycemia, hypoinsulinemia, hypothyroidism, hypercholesterolemia, hypertriglyceridemia and an increased activity of liver enzymes. Fosinopril treatment prevented blood pressure elevation, resumed heartbeats to normal levels and significantly decreased the index of heart hypertrophy and body weight loss. It also ameliorated STZ- induced hyperglycemia, hypoinsulinemia and hypothyroidism of diabetic and diabetic hypertensive rats. The lipid profile and liver enzymes pictures were also improved