Antimicrobial studies on fractions and pure compounds of caulophyllum inophllum Linn

ABSTRACT

An evergreen medicinal plant, Calophyllum inophyllum Linn. [Guttiferae], is cultivated as an ornamental plant through out Pakistan and medicinally used as antiseptic, astringent, expectorant, analgesic, diuretic and purgative. The chemical investigations revealed organic compounds viz. cholesterol, friedelin, canophyllol, canophyllic acid, inophynone, isoinophynone, 1,4, 5, 6 - tetrahydroxy - 2 - oxo - cycloheptene and biological studies [anti - bacterial and anti- fungal activities] of fractions [n - butanol, ethanol, chloroform and aqueous] and pure compounds [friedelin, canophyllol, canophyllic acid and inophynone] showed significant and non - significant results against Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium diphtheriae, Bacillus subtilis [Gram + ve], Escherichia coli, Salmonella typhi, Shigella boydii, Klebsiella pneumonia, Proteus mirabilis, Pseudomonas aeroginosa [Gram - ve], Epidermophyton floccosum, Trichophyton rubrum, T. schoenleinii, Pseudallescheria boydii, Candida albicans, Aspergillus niger [human pathogens], Microsporum canis, Trichophyton simii, T. metagrophyton [animal pathogens], Fusarium oxysporum var. lycopersici, F. solani var. lycopersici, Macrophomina phaseolina [plant pathogens]