Hypomagnesemia; a risk factor for chronic vascular complications in diabetes mellitus

ABSTRACT

A comparative study was carried out in 60 total diabetic patients with chronic vascular complications including, 20 having cardiovascular complications, 20 with retinopathy, 20 with peripheral neuropathy and 60 total diabetic patients without complications to find out any correlation of serum magnesium level with the diabetic state and any significant association with specific complications. Serum magnesium as found to be significantly decreased [P<0.001] and this correlates inversely with serum glucose, urine magnesium, urine sugar and glycosylated haemoglobin [HbA1c] which are to be significantly increased in all the groups of diabetic patients with complications where as no significant change in serum insulin was seen among the diabetics with and without complications. Serum level of triglycerides, LDL cholesterol remained significantly higher [P<0.001] whereas HDL cholesterol shared significantly [P<0.001] lower in all diabetic patients with complications while total cholesterol shared significant increase [P<0.01] in only patients having cardiovascular complications. A significant increase [P<0.01] in the level of uric acid in retinopathy and peripheral neuropathy and a non significant level in cardiovascular complications group whereas serum albumin is entirely non significant in diabetic patients with complication as compared to diabetic without complications