Kinetics of drugs in micellar systems

ABSTRACT

Kinetic behaviour of various esters like procaine, benzocaine and methyl paraben employed in many pharmaceutical formulations has been investigated in micellar systems. Micellar systems comprise an anionic surfactant [Sodium Dodecyl Sulphate, SDS] and a non-ionic one [Tween 80]. The study reveals that over a ten fold increase in the concentration of these drugs does not bring any significant change in the rate constant of the respective ester in any aqueous micellar environment