Structure activity relationship of some new phenethylamine analogues

ABSTRACT

Discovery of L-dopa, isoprenaline, ephedrine and other catecholamines as effective therapeutic agents in cardiac and respiratory diseases initiated our interest to synthesize similar types of compounds possessing potentiating effect and lesser side effects and toxicity. The research, therefore carried out consisted of the synthesis, spectroscopic and biological studies of some new phenethylamine analogues. Some of these products exhibited significant cardiac activity on the heart of frog on the basis of which certain speculations were made regarding their structure activity relationships